By Tarun Sai LomteJul 6 2023Reviewed by Lily Ramsey, LLM A recent study posted to medRxiv* preprint server tested whether healthy diets slowed biological aging and, thus, dementia.
Biological processes associated with healthier diets and lower risk of dementia include the reversal of hallmarks of aging, such as metabolic regulation and lower oxidative stress and inflammation. About the study In the present study, researchers tested whether people eating healthier diets had a slower pace of aging in the Framingham heart study that followed three generations of individuals. They analyzed data from the offspring cohort that commenced in 1971, involving the second generation of participants who were since followed up every four to seven years.
Subjects were flagged for additional assessment if 1) they reported subjective cognitive impairment, 2) they were referred by the physician/investigator, or 3) their mini-mental state examination scores were lower than education-based cut-offs. These flagged subjects underwent additional neuropsychologic and neurologic examinations.
Individuals with greater adherence to dietary guidelines were older, married, less likely to be smokers, and had higher education and physical activity but lower body mass index . During the follow-up, dementia was diagnosed in 129 subjects, and 432 deaths occurred.
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