Study suggests licorice-derived liquiritigenin has breast cancer prevention potential for high-risk postmenopausal women

By Pooja Toshniwal PahariaJun 1 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in Scientific Reports, researchers evaluated the potential of three licorice species, i.e., G. glabra , G. uralensis , and G. infata , and hops , and their main bioactive polyphenols, to prevent breast malignancy.

About the study In the present study, researchers reported on licorice-derived liquiritigenin’s promising potential to prevent breast cancer via inhibiting aromatase and protein synthesis among women at increased risk of breast cancer. In vivo experiments were performed using female Sprague-Dawley rats; following LigF’s demonstrated safety in estrogen-responsive tissues such as the uterus of rats, LigF-exposed breast tissue samples of high-risk postmenopausal women were subjected to transcriptomic analysis. The transcriptomic findings of decreased cellular proliferation, as indicated by changes in protein biosynthesis, were verified by performing live imaging of LigF-exposed Michigan Cancer Foundation -7 cells.

LigF demonstrated estrogenic effects in vitro; however, via estrogen receptor-beta activity, LigF significantly decreased estrogen-induced growth of the uterus in vivo and downregulated ribonucleic acid translatory mechanisms, protein synthesis, and amino acid metabolism among breast tissues of high-risk women. Repeated doses of LigF administered every two days also retarded the proliferation of Michigan Cancer Foundation-7 cells.

Health Health Latest News, Health Health Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

Researchers find oldest evidence of the plague in BritainScientists discover 4,000 year-old plague DNA - the oldest evidence of the disease in Britain.
Source: BBCScienceNews - 🏆 87. / 53 Read more »

Q&A: Researchers discover new, more effective candidates for treatment of syphilisSince 2000, sexually transmitted infection rates have been on the rise. Syphilis, a disease that was nearly eradicated in the United States at that time, now affects more than 18 million people worldwide each year with few options for effective treatment.
Source: medical_xpress - 🏆 101. / 51 Read more »

Researchers identify several new genetic risk factors for Alzheimer's disease unique to Ashkenazi JewsAlzheimer's disease (AD), the most common neurodegenerative disorder in the world, affects individuals of all races and ethnicities; however, most genetic research for AD has been performed on individuals of European ancestry (EA) with a limited number of large-scale genetic studies in other populations.
Source: medical_xpress - 🏆 101. / 51 Read more »

Researchers link death in gene-editing study to a virus used to deliver the treatment, not CRISPRThe lone volunteer in a gene-editing study targeting a rare form of Duchenne muscular dystrophy likely died after having a reaction to the virus that delivered the therapy in his body, researchers concluded in an early study.
Source: medical_xpress - 🏆 101. / 51 Read more »

Volunteering May Boost Kids' Well-Being, Study SaysIt's associated with better mental and physical health.
Source: TIME - 🏆 93. / 53 Read more »