The lone volunteer in a gene-editing study targeting a rare form of Duchenne muscular dystrophy likely died after having a reaction to the virus that delivered the therapy in his body, researchers concluded in anTerry Horgan, 27, of Montour Falls, New York, died last year during one of the first tests of a gene-editing treatment designed for one person. Some scientists wondered if the gene-editing tool CRISPR played a part in his death.
Horgan appears to have had a more severe immune reaction"than others receiving similar or slightly higher doses" of the virus, the authors wrote in the study, which has not yet been peer-reviewed.
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