]. Participants were recruited via 18 secondary schools across Cambridgeshire and Suffolk, UK from 2005 to 2006. At baseline, when participants were mean age 14·5 years , demographic and psychosocial measures were self-reported. Six months later, a sub-study was conducted focussing on diet, physical activity and body composition, in which participants completed a diet diary and simultaneously wore an activity monitor uninterrupted for four consecutive days.
]. Where sleep onset and sleep end times could not be ascertained from the activity plots, these cases were excluded. Prior to assessing sleep timings on this dataset, the researcher completed a training dataset discussing any discrepancies with a physical activity measurement specialist.Participants were provided with a 4-day diet diary to complete, which included two weekdays and two weekend days.
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Molecular mechanisms of microRNA-216a during tumor progression - Cancer Cell InternationalMicroRNAs (miRNAs) as the members of non-coding RNAs family are involved in post-transcriptional regulation by translational inhibiting or mRNA degradation. They have a critical role in regulation of cell proliferation and migration. MiRNAs aberrations have been reported in various cancers. Considering the importance of these factors in regulation of cellular processes and their high stability in body fluids, these factors can be suggested as suitable non-invasive markers for the cancer diagnosis. MiR-216a deregulation has been frequently reported in different cancers. Therefore, in the present review we discussed the molecular mechanisms of the miR-216a during tumor progression. It has been reported that miR-216a mainly functioned as a tumor suppressor through the regulation of signaling pathways and transcription factors. This review paves the way to suggest the miR-216a as a probable therapeutic and diagnostic target in cancer patients.
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