Abnormal 12-Hour Cyclic Gene Activity Found in Schizophrenic Brains

Twelve-hour rhythms in the human dorsolateral prefrontal cortex are abnormal in schizophrenia. Credit: Colleen A. McClung Created with biorender.com.

It is well established that individuals with schizophrenia experience disruptions in various 24-hour bodily rhythms, including their sleep-wake patterns, hormone levels, and gene activity in the prefrontal cortex of the brain. However, there is limited understanding of gene activity in the brain, both in healthy individuals and those with schizophrenia, for rhythms that are shorter than the typical 24-hour circadian rhythm.

The researchers found numerous genes in the normal dorsolateral prefrontal cortex that have 12-hour rhythms in activity. Among them, gene activity levels related to building connections between neurons peaked in the afternoon/night, while those related to mitochondrial function peaked in the morning/evening.

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