[11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial - Nature Medicine

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Comparison of non-invasive 11C-metomidate PET-CT with adrenal vein sampling for predicting biochemical remission of primary aldosteronism demonstrated non-superiority, suggesting it is suitable as a method for diagnosis of unilateral primary aldosteronism

Secondary outcomes were compared between patients who underwent surgery and those who did not and, for those who underwent surgery, between those for whom surgery was indicated by AVS only, MTO only or both tests.

For each of the primary outcomes, a sensitivity analysis was carried out to assess the impact of including patients for whom AVS was classified as failed. A bootstrap procedure was applied, sampling with replacement from the 78 patients who underwent surgery. Sampling was stratified by whether AVS was successful or failed.

 

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