]. However, we could not identify any cases describing the development of cSLE or exacerbation of lupus nephritis during childhood. We report a pediatric patient who developed clinical symptoms of cSLE two days after administration of the 3rd dose of the SARS-CoV2 vaccination; he also had nephrotic-range proteinuria and a kidney biopsy demonstrated class V lupus nephritis.
At his pediatrician visit three weeks after the vaccine, labs were notable for a positive antinuclear antibody and positive autoantibodies against double-stranded deoxyribonucleic acid , Ro, Smith and ribonucleoprotein . He also had hypocomplementemia and an elevated erythrocyte sedimentation rate .
The patient was subsequently evaluated in pediatric rheumatology clinic five weeks after the COVID-19 vaccination. His blood pressure was 115/63, which is mildly elevated for age, sex and height . His positive physical exam findings included arthritis of bilateral elbows, palatal erythema, maculopapular malar rash on face with flat, violaceous lesions on extremities. Patient also had capillary loop dilatation on nailfold capillaroscopy.
Laboratory evaluation at his initial rheumatology clinic visit included leucopenia , hemoglobin of 14.1 g/dL, platelet count of 140,000 per µl, hypoalbuminemia , elevated ESR and normal C-reactive protein. Repeat serology testing confirmed a positive ANA with a titer of 1:1280 and positive anti-dsDNA, anti-Smith, anti-RNP, and anti-Ro antibodies. The patient’s anti-histone antibody was also found to be high-titer positive .
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Impact of easing COVID-19 lockdown restrictions on traumatic injuries in Riyadh, Saudi Arabia: one-year experience at a major trauma centre - BMC Public HealthIntroduction Lockdown restrictions due to the COVID-19 pandemic have reduced the number of injuries recorded. However, little is known about the impact of easing COVID-19 lockdown restrictions on the nature and outcome of injuries. This study aims to compare injury patterns prior to and after the easing of COVID-19 lockdown restrictions in Saudi Arabia. Method Data were collected retrospectively from the Saudi TraumA Registry for the period between March 25, 2019, and June 21, 2021. These data corresponded to three periods: March 2019–February 2020 (pre-restrictions, period 1), March 2020–June 2020 (lockdown, period 2), and July 2020–June 2021 (post easing of restrictions, period 3). Data related to patients’ demographics, mechanism and severity of injury, and in-hospital mortality were collected and analysed. Results A total of 5,147 traumatic injury patients were included in the analysis (pre-restrictions n = 2593; lockdown n = 218; post easing of lockdown restrictions n = 2336). An increase in trauma cases (by 7.6%) was seen in the 30–44 age group after easing restrictions (n = 648 vs. 762, p | 0.01). Motor vehicle crashes (MVC) were the leading cause of injury, followed by falls in all the three periods. MVC-related injuries decreased by 3.1% (n = 1068 vs. 890, p = 0.03) and pedestrian-related injuries decreased by 2.7% (n = 227 vs. 143, p | 0.01); however, burn injuries increased by 2.2% (n = 134 vs. 174, p | 0.01) and violence-related injuries increased by 0.9% (n = 45 vs. 60, p = 0.05) post easing of lockdown restrictions. We observed an increase in in-hospital mortality during the period of 12 months after easing of lockdown restrictions—4.9% (114/2336) compared to 12 months of pre-lockdown period—4.3% (113/2593). Conclusion This is one of the first studies to document trauma trends over a one-year period after easing lockdown restrictions. MVC continues to be the leading cause of injuries despite a slight decrease; overall injury cases rebounded towards pre
Source: BioMedCentral - 🏆 22. / 71 Read more »
Overcoming and mitigating ethical issues raised by artificial intelligence in health and medicine: The search continues - BMC Series blogAs the implementation of artificial intelligence (AI)-based innovations in health and care services become more and more common, it is increasingly pressing to address the ethical challenges associated with AI in healthcare to find appropriate solutions. In the cross-journal BMC collection Ethics of Artificial Intelligence in Health and Medicine, we urge the research communities, industry, policy makers and other stakeholders to join forces in tackling the grand challenges of realising Ethical and fair AI in health and medicine.
Source: BioMedCentral - 🏆 22. / 71 Read more »
China claims it has 'passed peak' of Covid surge as it reports 60,000 deathsChina claims it has 'passed peak' of Covid surge as it reports 60,000 deaths 🔴 Chinese officials shared data after criticism from the World Health Organisation, but experts say they are still far lower than thought
Source: i newspaper - 🏆 8. / 89 Read more »