Fwas equal to 10 suggesting that weak instrument bias may influence the analyses for men . We evaluated heterogeneity and pleiotropy to test the “exchangeability” and “exclusion restriction” assumptions . There was evidence of heterogeneity in most of the analyses as denoted by the: Tables S7 and S8).
Relatively few observational studies have examined the relationship between early life body size and risk of later life colorectal cancer. A joint Nurses’ Health Study and Health Professionals Follow-up Study found that higher body fatness in early life was associated with greater colorectal cancer risk for women but not men with similar results across cancer sub-sites [
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The gut microbiota in multiple sclerosis varies with disease activity - Genome MedicineBackground Multiple sclerosis is a chronic immune-mediated disease of the brain and spinal cord resulting in physical and cognitive impairment in young adults. It is hypothesized that a disrupted bacterial and viral gut microbiota is a part of the pathogenesis mediating disease impact through an altered gut microbiota-brain axis. The aim of this study is to explore the characteristics of gut microbiota in multiple sclerosis and to associate it with disease variables, as the etiology of the disease remains only partially known. Methods Here, in a case-control setting involving 148 Danish cases with multiple sclerosis and 148 matched healthy control subjects, we performed shotgun sequencing of fecal microbial DNA and associated bacterial and viral microbiota findings with plasma cytokines, blood cell gene expression profiles, and disease activity. Results We found 61 bacterial species that were differentially abundant when comparing all multiple sclerosis cases with healthy controls, among which 31 species were enriched in cases. A cluster of inflammation markers composed of blood leukocytes, CRP, and blood cell gene expression of IL17A and IL6 was positively associated with a cluster of multiple sclerosis-related species. Bacterial species that were more abundant in cases with disease-active treatment-naïve multiple sclerosis were positively linked to a group of plasma cytokines including IL-22, IL-17A, IFN-β, IL-33, and TNF-α. The bacterial species richness of treatment-naïve multiple sclerosis cases was associated with number of relapses over a follow-up period of 2 years. However, in non-disease-active cases, we identified two bacterial species, Faecalibacterium prausnitzii and Gordonibacter urolithinfaciens, whose absolute abundance was enriched. These bacteria are known to produce anti-inflammatory metabolites including butyrate and urolithin. In addition, cases with multiple sclerosis had a higher viral species diversity and a higher abundance of Caudovirales b
Source: BioMedCentral - 🏆 22. / 71 Read more »
Fully automated closed-loop insulin delivery in adults with type 2 diabetes: an open-label, single-center, randomized crossover trial - Nature MedicineIn a randomized, crossover trial in adults with type 2 diabetes, fully closed-loop insulin delivery increased time in target glucose range compared with standard insulin therapy, without increasing hypoglycemia.
Source: medical_xpress - 🏆 101. / 51 Read more »
Impact of a remote lifestyle coaching program on the length of hospital stay and complications in patients undergoing knee and hip arthroplasty surgery - On MedicineIn a blog about the optimization of patients for surgery, Dr Rebecca Barker discusses SAPIEN, a study of a remote lifestyle coaching program for patients undergoing knee and hip arthroplasty surgery, registered at the ISRCTN registry.
Source: BioMedCentral - 🏆 22. / 71 Read more »
Trust us: everyone is going to be talking about ITV’s MaternalThe series follows three women balancing their lives as new mothers alongside their demanding jobs in post-pandemic frontline medicine.
Source: StylistMagazine - 🏆 133. / 51 Read more »
Trust us: everyone is going to be talking about ITV’s Maternal next weekAre you looking for a new TV series to get stuck into? Look no further than ITV’s Maternal, then, which is set to shine a spotlight on the “women on the NHS frontline who are holding it together.”
Source: StylistMagazine - 🏆 133. / 51 Read more »