“By targeting these proteins, we may be able to more successfully treat or even prevent those injuries,” he said.
In dry eye disease, the eye can't provide adequate lubrication with natural tears. Various types of drops can help replace those, but when the eyes are dry, thethat regenerate the cornea may be new targets for treating and preventing such injuries. To study this, the investigators analyzed genes expressed by the cornea in several mouse models. They looked at dry eye disease,In mice with dry eye, the cornea activated a gene called SPARC. Higher levels of the SPARC protein were associated with better healing.
“We conducted single-cell RNA sequencing to identify genes important to maintaining the health of the cornea, and we believe that a few of them, particularly SPARC, may provide potential therapeutic targets for treating dry eye disease and corneal injury,” said first author Joseph Lin, an MD/PhD student in Apte's lab.
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