By Bhavana KunkalikarJan 4 2023Reviewed by Danielle Ellis, B.Sc. In a recent review published in Advances in Food and Nutrition Research, researchers assessed the function of lipids in metabolic diseases.
Lipid metabolism and lipotoxicity Lipotoxicity and its significance Lipotoxicity is described as the deleterious impact of the collection of fats and their corresponding metabolites in the vicinity of the adipose tissue. The elevated levels of lipids adversely affect cellular homeostasis while disrupting tissue function.
Hence, immunometabolic pathways are associated with lipotoxicity. Similarly, as lipotoxicity leads to inflammation, lipid metabolism changes can result in immune system alterations. This results in a vicious cycle that can lead to several chronic diseases. Antibodies eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Furthermore, higher levels of docosahexaenoic acid and eicosapentaenoic acid can disturb the homeostasis towards less inflammatory phenotypes. It has also been suggested that the ability of dietary FAs to act differently on distinct cells involved in the immune response that impact systemic inflammation can be employed to treat metabolic disorders.
Lipotoxicity and metabolic reprogramming Metabolic reprogramming is the ability of certain cells, like tumor cells, to alter their metabolism to satisfy high energy requirements, which may cause rapid growth and proliferation. Changes in lipid metabolism play an important role in the biology of tumor cells.
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