IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma - Nature Medicine

We are very grateful to all patients who contributed samples and participated in the study. We thank all the staff of the Day Treatment Unit, Oxford Cancer Centre and the Brodey Centre at the Horton General Hospital. We are grateful to all the staff of the Oxford University Hospitals NHS Foundation Trust haematology and biochemistry laboratory and thank T. James for his facilitation, as well as the staff of the Oxford Radcliffe Biobank and Churchill Hospital Sample Handling Lab.

Chelsea A. Taylor, Robert A. Watson, Orion Tong, Weiyu Ye, Isar Nassiri, James J. Gilchrist, Alba Verge de los Aires, Piyush Kumar Sharma, Surya Koturan, Rosalin A. Cooper, Victoria K. Woodcock, Elsita Jungkurth & Benjamin P. FairfaxChelsea A. Taylor, Robert A. Watson, Orion Tong, Weiyu Ye, Isar Nassiri, Alba Verge de los Aires, Piyush Kumar Sharma, Surya Koturan, Rosalin A. Cooper, Victoria K. Woodcock, Elsita Jungkurth, Mark R. Middleton & Benjamin P.

Oxford Cancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, UK Robert A. Watson, Victoria K. Woodcock, Nicholas Coupe, Miranda J. Payne, David N. Church, Mark R. Middleton & Benjamin P.

Department of Medical Oncology, Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USAStefan Groha, Matthew L. Freedman, Toni K. Choueiri & Alexander GusevLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UKNational Institute for Health Research Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UKLank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA, USAToni K. ChoueiriMark R.

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Eight rules to combat medical misinformation - Nature MedicineAuthors of biomedical research should provide clear and accurate information to society, whilst working to combat misinformation and disinformation. CT_Bergstrom Interesting indeed; I wished the author has addressed the intentional misinformation made by scientists driven by political and ideological prejudices. CT_Bergstrom Carl, you still have good points... but also, you still need to listen to your own advice. Conflating FL's substantive reasons for pursuing its policies with unthouthful, reactionary responses is itself disingenuous and poor communication. Do better. You too, NM! CT_Bergstrom A bunch of glittering generalities with no actual information.
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Leukocyte telomere length in children born following blastocyst-stage embryo transfer - Nature MedicineAnalyses of whole-genome sequencing data in children and validation in mouse models show that offspring born from blastocyst-stage embryo transfer have shorter leukocyte telomere lengths.
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The context, science and practice of gender-affirming care - Nature MedicineThe context, science and practice of gender-affirming care for transgender and gender diverse people. Comment from Alex S. Keuroghlian, JoAnne Keatley, Simran Shaikh & AsaRadix, FenwayHealth CallenLorde AsaRadix FenwayHealth CallenLorde Is largely unscientific, in examined, uncritical and for all is self proclaimed empathising denies persons in distress the most important element of effective healthcare. Oh? You don't know? AsaRadix FenwayHealth CallenLorde What any person in distress benefits from most is an independent assessment of their predicament informing suggestions for remedial action. Often now denied by axe grinding 'therapists'.
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Germline variants associated with toxicity to immune checkpoint blockade - Nature MedicineA genome-wide association study in large cohorts of patients with different types of cancer treated with immune checkpoint inhibitors identifies genetic variants associated with immune-related adverse events immunotherapy GrohaStefanDrChoueiri
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