The 13-year-old girl, identified only as Alyssa, was diagnosed with T-cell acute lymphoblastic leukemia in 2021.
In 28 days her cancer was in remission, allowing her to receive a second bone marrow transplant to restore her immune system. Robert Chiesa, a GOSH consultant, said her turnaround had been "quite remarkable," although the results still needed to be monitored and confirmed in the next few months.Acute lymphoblastic leukemia is the most common kind of cancer in children and affects cells in the immune system, known as B cells and T cells, which fight and protect against viruses.
But to treat some other types of leukemia the team had to overcome the challenge that T cells designed to recognize and attack cancerous cells had ended up killing each other during the manufacturing process. "It's our most sophisticated cell engineering so far and paves the way for other new treatments and ultimately better futures for sick children."
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