The dual specificity lipid/protein phosphatase SHIP1 is enriched in myeloid cells. Single nucleotide polymorphisms incoding and non-coding regions impact risk for developing late onset sporadic Alzheimer’s disease .
We present pathological analyses with spatial transcriptomics of mice with tamoxifen-sensitive microglial knockdown ofand show exacerbated plaque pathology, plaque-associated microglial density, and altered gene expression around plaques, suggesting novel markers for plaque-associated reactive microglia.SAL is a founder of AstronauTx Ltd. All other others declare no competing interests.
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INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer’s diseaseThe dual specificity lipid/protein phosphatase SHIP1 (encoded by the INPP5D gene) is enriched in myeloid cells. Single nucleotide polymorphisms (SNPs) in INPP5D coding and non-coding regions impact risk for developing late onset sporadic Alzheimer’s disease (LOAD). We present pathological analyses with spatial transcriptomics of mice with tamoxifen-sensitive microglial knockdown of Inpp5d and show exacerbated plaque pathology, plaque-associated microglial density, and altered gene expression around plaques, suggesting novel markers for plaque-associated reactive microglia. Competing Interest Statement SAL is a founder of AstronauTx Ltd. All other others declare no competing interests.
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