Increased risk for all-cause dementia in people who abstain from alcohol

Study: The relationship between alcohol use and dementia in adults aged more than 60 years: a combined analysis of prospective, individual-participant data from 15 international studies. Image Credit: Ground Picture / Shutterstock

One of the critical risk factors mentioned in the report was excessive alcohol consumption in mid-life – owing to the significant neurotoxic effects of ethanol on the brain. In addition, population-based studies have also associated heavy alcohol use with dementia. The study included 15 epidemiological cohort studies – members of the Cohort Studies of Memory in an International Consortium collaboration. Individuals with dementia diagnosis at baseline, those without follow-up after dementia assessment, and those with no alcohol use records were excluded.

Notably, the risk of dementia was greater among alcohol abstainers than occasional, light- to moderate-, and moderate- to heavy drinkers. This result was consistent among the female subjects and the fully adjusted and competing risk models. However, in fully adjusted models and in those adjusted for competing for risk for death among females, no association was found between alcohol use and dementia.

Furthermore, dementia risk did not differ between daily drinkers and occasional drinkers. The same was true in comparison between lifetime abstainers and current drinkers.

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