Nutritional approaches targeting gut microbiome could improve brain disorders

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Nutritional approaches targeting gut microbiome could improve brain disorders Brain Microbiome Bacteria Clinical Depression Diet Neurology Diet MentalHealth microbiota gutbrainaxis CO_CNutritionMC UCC

By Suchandrima BhowmikSep 15 2022Reviewed by Danielle Ellis, B.Sc. Microbiomes refer to the collective genomes of microorganisms living in a particular environment. The microbiota refers to the community of microbes themselves. For example, the human gastrointestinal tract contains approximately 100 trillion microorganisms . These microorganisms play essential roles in immunity and energy metabolism in humans, extending from gastrointestinal health to brain behavior and function.

Study: Diet and the microbiota–gut–brain-axis: a primer for clinical nutrition. Image Credit: Pikovit / Shutterstock A healthy diet comprising live bacteria or phytochemicals can promote the production of SCFA and other bioactive compounds that can positively impact metabolic and gastrointestinal health and brain processes.

Fermented foods such as kombucha, kefir, and yogurt have also been reported to improve metabolic and gastrointestinal health. However, studies on their impact on brain and behavior outcomes are limited. Other diet-related methods for targeting the microbiota–gut-axis include intermittent fasting and ketogenic diets.

Objective methods such as nutritional biomarkers are free from misreporting issues and bias. Some nutritional biomarkers include total vitamins and minerals in the urine, plasma, serum, energy intake, phytochemicals, caffeine metabolites, isoflavones, carotenoids, and phytosterols. However, using nutritional biomarkers along with self-reported data is found to provide optimal results.

 

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