A team of researchers led by the Bork group at EMBL Heidelberg, along with their collaborators in the Netherlands and Australia, has now used this unusual medical procedure to ask a fascinating question—what happens when two gut microbiomes mix together?
The answer could hold clues to better therapeutic strategies for gut disorders as well as a richer understanding of howhave demonstrated that FMTs can effectively treat certain gut disorders, their mode of action remains unclear. Some hypothesize the gut microbiomes of donors have beneficial properties that help return the recipient's gut to a healthy state. However, this has never been systematically studied.
"The 'super donor' hypothesis is widely held among practitioners: it postulates that finding 'good' donors is essential to the clinical success of an FMT and that a good donor will work for many different patients," said Sebastian Schmidt, one of the first authors of a new study published inHowever, using clinical and metagenomics data from over 300 FMTs, the researchers discovered that it's probably the recipient and not the donor that primarily determines the...
The team developed a machine-learning approach to dissect the factors that determine microbial dynamics after an FMT, including the presence or absence of individual microbial species. Their results show that
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