By Dr. Chinta SidharthanSep 6 2022Reviewed by Danielle Ellis, B.Sc. In a review paper published in The Journal of Clinical Investigation, researchers discussed possible mechanisms and potential treatment methods for endotheliopathy observed in patients with post-acute sequelae of severe acute respiratory syndrome coronavirus 2 infection .
Many of the studied PASC cases resulted from infections with the first SARS-CoV-2 strain or its early variants. Still, the possibility of PASC after infections with the recent variants cannot be ruled out. Despite being a widely reported post-COVID-19 occurrence, the pathophysiology and standard treatment options are still unknown, highlighting the need to understand the possible mechanisms of PASC better and explore potential therapeutic avenues.
Studies investigating hematologic and immunologic markers such as absolute neutrophil count, levels of C-reactive protein, ferritin, interleukin receptors 2 and 6, lactate dehydrogenase levels, and liver function tests were also reviewed. The impact of comorbidities and demographic parameters such as hypertension, obesity, sex, age, diabetes mellitus, and cancer were compared between acute COVID-19 and PASC.
Many studies showed no correlation between the development of PASC and demographic factors or comorbidities such as age, type of diabetes mellitus, hypertension, and body mass index. Sexual phenotype, however, did correlate with the occurrence of PASC, with females showing a greater reduction in the progression of COVID-19 but a higher tendency to develop PASC.
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