Turning Cancer Cells Into Normal Cells

Cancer of the body’s blood-forming tissues, such as the lymphatic system and bone marrow, is known as leukemia.A recent study explains how changing the chemical modifications, or so-called epigenetics, of a specific type of leukemia cell’s genetic material, the messenger, leads to the transformation of highly proliferative leukemia cells into normal cells that no longer multiply., is authored by Alberto Bueno-Costa, a researcher in the group of Dr.

“We know that one strategy that human tumors have to dodge the effectiveness of drugs is to change their appearance, becoming another similar cancer but insensitive to the drug used. For example, leukemias of the lymphoid lineage are switched to the myeloid strain to escape treatment”, explains Dr. Esteller.

This change in the chemical accentuation of these molecules causes instability of the proteins that define leukemia while favoring the appearance of differentiated proteins characteristic of the normal cell that is being born, the macrophage. This process appears to be controlled by the METTL3 gene, a manufacturer of chemical modifications targeting messenger RNA.

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