School of Medicine, an FDA-approved medicine used to control blood sugar in people with Type 2 diabetes may help reduce blood vessel dysfunction associated with aging.Researchers first investigated the effect of aging on human blood artery function and stiffness. The researchers then looked at how the sodium-glucose co-transporter 2 inhibitor empagliflozin affected blood vessel function and arterial stiffness in elderly male mice.
The scientists first compared blood vessel function and stiffness in 18 healthy human patients with an average age of 25 to 18 patients with an average age of 61. When compared to the younger patients, the older patients exhibited reduced endothelial function and increased aortic stiffness. In order to investigate the effects of Empa on vascular aging, 72-week-old male mice were divided into two groups. Twenty-nine were fed for six weeks with a diet enriched with Empa, while the other half were given standard food. After analyzing both groups six weeks later, researchers discovered the mice treated with Empa experienced improved blood vessel function, reduced arterial stiffness, and other vascular benefits.
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