A Belfast woman who has terminal cancer has said her outlook is worse due to the 13-month delay to be diagnosed.The mother of three had noticed changes to her breasts after childbirth and raised her concerns a number of times. She told BBC News NI she had months of symptoms.
In March, 48.1% of patients commenced their first treatment for cancer following an urgent referral within the 62 day target. At the end of March, 156,270 patients in Northern Ireland were waiting for a diagnostic test - a rise of 13.9% compared to the same quarter the previous year. A referral to the breast clinic also diagnosed mastitis and the IT consultant was told a scan was not possible as she was breastfeeding.
This will only get worse, there are thousands walking around unaware they are in her predicament
A courageous women.
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:
Health Health Latest News, Health Health Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Ceritinib is a novel triple negative breast cancer therapeutic agent - Molecular CancerBackground Triple-negative breast cancers (TNBCs) are clinically aggressive subtypes of breast cancer. TNBC is difficult to treat with targeted agents due to the lack of commonly targeted therapies within this subtype. Androgen receptor (AR) has been detected in 12–55% of TNBCs. AR stimulates breast tumor growth in the absence of estrogen receptor (ER), and it has become an emerging molecular target in TNBC treatment. Methods Ceritinib is a small molecule inhibitor of tyrosine kinase and it is used in the therapy of non-small lung cancer patients. Enzalutamide is a small molecule compound targeting the androgen receptor and it is used to treat prostate cancer. Combination therapy of these drugs were investigated using AR positive breast cancer mouse xenograft models. Also, combination treatment of ceritinib and paclitaxel investigated using AR− and AR low mouse xenograft and patient derived xenograft models. Results We screened 133 FDA approved drugs that have a therapeutic effect of AR+ TNBC cells. From the screen, we identified two drugs, ceritinib and crizotinib. Since ceritinib has a well- defined role in androgen independent AR signaling pathways, we further investigated the effect of ceritinib. Ceritinib treatment inhibited RTK/ACK/AR pathway and other downstream pathways in AR+ TNBC cells. The combination of ceritinib and enzalutamide showed a robust inhibitory effect on cell growth of AR+ TNBC cells in vitro and in vivo. Interestingly Ceritinib inhibits FAK-YB-1 signaling pathway that leads to paclitaxel resistance in all types of TNBC cells. The combination of paclitaxel and ceritinib showed drastic inhibition of tumor growth compared to a single drug alone. Conclusions To improve the response of AR antagonist in AR positive TNBC, we designed a novel combinational strategy comprised of enzalutamide and ceritinib to treat AR+ TNBC tumors through the dual blockade of androgen-dependent and androgen-independent AR signaling pathways. Furthermore, we introduced LSU TNBC circadian rhythm healthequity breastcancer The risk of triple negative breast cancer (TNBC) is reduced by preventive healthcare that measures the diurnal cortisol rhythm and nocturnal melatonin amplitude and volume. .
Source: medical_xpress - 🏆 101. / 51 Read more »
Breast cancer: 'I knew my body wasn't right''I knew my body wasn't right' Woman who has terminal cancer says her outlook is worse due to 13-month delay to be diagnosed This must be one of those brexit winnings the brexiteers told us about. An underfunded, short staffed national health service where profits come first and people second. This is happening very frequently now. And it's inexcusable because the signs are that it's not merely human error - it's happening because the NHS and doctors just don't seem to care enough anymore.
Source: BBCNews - 🏆 3. / 97 Read more »
Breast milk donations requested by Western Health TrustA service that helps premature and seriously-ill babies across the island of Ireland has appealed for more breast milk donors.
Source: BBCNewsNI - 🏆 95. / 52 Read more »