Ceritinib is a novel triple negative breast cancer therapeutic agent - Molecular Cancer

]. RTK-activated androgen-independent AR signaling may partially complement or compete with canonical AR signaling activity, which results in only modest efficacy of AR antagonism in AR positive TNBC treatments. Current AR-targeting studies focus on the blockade of the canonical AR signaling pathway, while the role of androgen independent AR signaling pathway in TNBCs is neglected.

Due to the observed inhibitory effects of ceritinib in the AR signaling cascade, we proposed that an AR inhibitor and ceritinib would be synergistic and more effective in a combination strategy. In this study, we discovered that the combination of enzalutmide and ceritinib is an effective regimen in AR−TNBC. The efficacy of these combination strategies were evaluated in multiple model systems.

This study has crucial implications in the field of drug and target discovery in the context of breast cancer. The results from our study have immediate implications for clinical translation for this difficult-to-treat breast cancer subtype, which would benefit significantly from effective targeted therapeutic regimens. Our innovative approach to test repurposed FDA-approved drugs in new clinical contexts can be applied to all cancer tumor types and is not limited to breast cancer.

LSU TNBC circadian rhythm healthequity breastcancer The risk of triple negative breast cancer (TNBC) is reduced by preventive healthcare that measures the diurnal cortisol rhythm and nocturnal melatonin amplitude and volume. .

Health Health Latest News, Health Health Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

Portsmouth Love Island star Demi Jones encourages cancer checksThe reality TV star shared her battle with thyroid cancer while being treated at hospital. Where's the top of his head? cast. Not a star. Amen Which one is Demi Jones?
Source: BBCNews - 🏆 3. / 97 Read more »

Piers Morgan and Adele Roberts lead tributes for Dame Deborah James after death‘Thank you for everything Deborah. Thank you for being so strong for so long and helping others when you were in so much pain yourself.' Adele Roberts and Piers Morgan have led tributes to Dame Deborah James, who has died at the age of 40. Rest in peace you sweet angel So sad 🙏🏻 Bless her wondwrful heart.
Source: MetroUK - 🏆 13. / 82 Read more »

Beloved podcaster Deborah James dies aged 40 after bowel cancer battleDeborah James, the beloved podcast host who chronicled her battle with bowel cancer, has died A fabulous woman. RIP Deborah. Sad news. Very, very sad. Thoughts with Deborah’s family, friends and all who have loved and appreciated her work regarding cancer, care and things that truly matter.
Source: LBCNews - 🏆 75. / 59 Read more »

“You are the best of us”: tributes paid to BowelBabe Dame Deborah James following her deathDame Deborah James, known as BowelBabe online, passed away from bowel cancer on 28 June
Source: StylistMagazine - 🏆 133. / 51 Read more »

Cancer conman duped pensioner out of thousandsHe claimed he needed cash to buy cancer drugs but spent it on a static caravan
Source: nottslive - 🏆 96. / 52 Read more »