What's the difference between a PCR and antigen COVID-19 test? A molecular biologist explains

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Rapid, accurate tests are essential to contain a highly contagious virus like SARS-CoV-2: PCR tests are accurate but can take a long time to produce results, while antigen tests are much faster, though less accurate.

. Each detects a different part of the virus, and how it works influences the test’s speed and relative accuracy. So what are the differences between these types of tests?Looking for genetic evidence

The first step for either kind of test is to get a sample from the patient. This can be a nasal swab or a bit of saliva. For PCR tests, the next step is amplification of genetic material so that even a small amount of coronavirus genes in the patient’s sample can be detected. This is done using a technique called a. A health care worker takes the sample and treats it with an enzyme that converts RNA into double-stranded DNA. Then, the DNA is mixed with a solution containing an enzyme called a polymerase and heated, causing the DNA to separate into two single-stranded DNA pieces.

 

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