Echoes of neurodegenerative disease in fatal COVID-19; sleep woes may add risk

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Poor sleep habits may be linked with higher risk for severe illness in patients with COVID-19, according to Harvard University researchers.

The brain inflammation and impaired “brain circuitry” seen in people who die of COVID-19 look a lot like what doctors see in the brains of people who die of neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease, researchers reported on Monday in the journal Nature.

Genes involved with cognition, schizophrenia and depression were more often “turned on” in the COVID-19 patients’ brains, they found. Participants had answered questions from 2006 to 2010 about sleep duration, daytime sleepiness, insomnia and body clocks. For the new study, based on their responses, the researchers assigned scores ranging from 0 to 6, with higher scores indicating multiple poor sleep “traits.”This was true even after researchers accounted for issues known to be risk factors for poor COVID-19 outcomes such as sleep apnea, obesity and smoking, they reported on Friday in the journal Clinical Infectious Diseases.

 

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