Takeda's dengue vaccine effective overall in study but with major limitation

CHICAGO: Takeda Pharmaceutical Co's experimental dengue vaccine was highly effective at preventing the mosquito-borne disease in a late stage study, but it failed to protect against one type of the virus in people with no prior exposure to dengue.

The results follow Sanofi's 2017 disclosure that Dengvaxia increased the risk of severe dengue in children who had no prior dengue exposure when they got the shot. "This is a fantastic result and we're thrilled," Derek Wallace, who runs Takeda’s global dengue vaccine program, said in a phone interview, noting that the results were similar between those who have and have not had dengue before.

There was no difference in effectiveness against dengue 2 among those with no prior exposure to dengue and those previously exposed, and a slightly lower benefit against dengue 1 for those with no prior exposure.

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