Seeking an Obesity Cure, Researchers Turn to the Gut Microbiome

While these findings were coming to light, scientists discovered that fecal transplants were afor Clostridium difficile, a devastating bacterial infection that often occurs when antibiotics decimate the healthy gut bacteria that keep it in check. Fecal transplants from healthy donors, administered through colonoscopy or capsules containing desiccated stool, reintroduce beneficial bacteria to the guts of ailing patients, providing resistance against C. difficile.

“The logic behind it falls apart,” he added. “It’s saying, because I don’t know what’s going on, let me just treat it with everything that I have and hope for the best.” At Mass General, Dr. Yu and her colleagues recruited 24 obese men and women with insulin resistance, along with four lean donors. The donors were screened for an array of medical conditions to ensure that they were healthy and would not transmit any infections to the recipients.

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