to seek out dope. This doesn’t reverse when you stop using — it can persist for years, if not indefinitely. For many, sobriety doesn’t get easier with time because it’s not physiologically possible.has been observed at the cellular level in opioid addicts’ brains. This includes an abnormal stress response and reduced connectivity between key areas involving reward processing.
Epidemiological studies point to an especially high comorbidity of opioid use and depression. Junkies who enter treatment are thought to be four times more likely to have a depressive disorder than the general population, and yet the overwhelming majority of mentally ill addicts in rehab receive addiction treatment only.
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