A drug that has been used to treat ovarian cancer since 2014 was approved last month by the Health Sciences Authority for treating late-stage breast cancer in patients with a rare genetic mutation.It kills cancer cells containing mutated BRCA1 and BRCA2 genes - which normally function as tumour suppressors - by inhibiting their ability to repair their DNA.
She said women with the mutation have a 50 per cent chance of developing breast cancer by age 50 compared with just 2 per cent for most other women. Prof Lee said women with a family history of breast and ovarian cancer should consider genetic testing, as should those diagnosed with breast cancer before age 40.One prominent example is Hollywood actress Angelina Jolie.
She tested positive for BRCA mutation and was later prescribed Olaparib in January last year under a compassionate access scheme as the HSA had not yet registered it for treating breast cancer here.
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