ARPA-H funding boosts Wyss Institute's RNA therapeutic project

Wyss Institute for Biologically Inspired Engineering at HarvardJul 15 2024 With the award for up to $27 million from the Advanced Research Projects Agency for Health , a collaborative research project at the Wyss Institute for Biologically Inspired Engineering at Harvard University will advance a disease-agnostic novel RNA therapeutic with the potential to treat diverse diseases, and to be effectively and rapidly deployable.

With its first focus on cancer as a disease target, the multidisciplinary Wyss team combines critical and highly complementary expertise in the areas of drug discovery, advanced in vitro and in vivo models for preclinical drug testing, innovative drug delivery, RNA nanotechnology, and next-generation RNA synthesis and manufacturing.

Origins and validation The project began in the middle of the COVID-19 pandemic, when Ingber's group identified a novel, structurally distinct double stranded RNA molecule that they showed prevents the replication of various potential pandemic respiratory viruses, including SARS-CoV-2 in an animal model as well as MERS-CoV, and various influenza viruses in human lung tissues engineered in Organ Chips.

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