Biomarkers of food intake: The key to precision nutrition

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Researchers examine the potential utility of biomarkers of food intake on objective and accurate dietary assessments.

By Dr. Liji Thomas, MDReviewed by Benedette Cuffari, M.Sc.Jul 5 2024 The crucial role of nutrition in health necessitates the development of dietary assessment tools capable of accurately assessing causal relationships with various health-related consequences.

A BFI is a metabolite of ingested food and is defined as a measure of the consumption of specific food groups, foods, or food components. BFIs can be ranked based on their robustness, in which minimal interference from a varied dietary background affects the use of the BFI in research. About the study Following validated BFI reviews that met appropriate guidelines and methodologies, the researchers performed two systematic searches for experimental and observational studies. Thereafter, a four-level classification system was used to rank reported BFIs based on their robustness, reliability, and plausibility.

Related StoriesLevel two candidate BFIs in urine include total plant foods and various plant foods including legumes and vegetables, dairy, and some specific fruits and vegetables. Blood BFIs at level two exist for plant foods, dairy products, some meat, and some non-alcoholic drinks; however, these BFIs comprise fewer foods with less validation.

Endogenous metabolites are poorly robust BFIs, as they are produced both endogenously and from exogenous foods. These metabolites are also associated with significant variations with inter-individual genetic and microbial differences.

 

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