Impaired communication between immune cells leads to cognitive impairment in female Alzheimer's patients

Brigham and Women's HospitalJul 3 2024 Lead author Neta Rosenzweig, PhD, of the Ann Romney Center for Neurological Diseases, and senior author Oleg Butovsky, PhD, of the Ann Romney Center and Gene Lay Institute of Immunology and Inflammation, share key messages from their paper "Sex-Dependent APOE4 Neutrophil-Microglia Interactions Drive Cognitive Impairment in Alzheimer's Disease" published in Nature Medicine.

We also asked whether APOE4 regulates neutrophils in a cell-autonomous manner and whether deleting APOE4 in neutrophils could affect microglial phenotype and AD pathology in mouse models. Related StoriesIn collaboration with Reisa Sperling, MD, and Hyun-Sik Yang, MD, both of the Brigham's Department of Neurology , we isolated blood neutrophils from healthy controls and Alzheimer's disease donors expressing different APOE variants.

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