The U.S. Food and Drug Administration gave a green light to Eli Lilly's donanemab for patients with early Alzheimer's, making it the second approved drug for slowing the progress of the brain-wasting disease.A new Alzheimer's drug, donanemab, is giving new hope to those living with the condition, but it doesn't come without side effects and it's not a cure. Dr. Roger Wong, a clinical professor of geriatric medicine goes over why it's a big deal and what are the risks.U.S.
This view shows tests for patients with Alzheimer's disease at a memory clinic. Alzheimer’s disease is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills and, eventually, the ability to carry out simple tasks. "It's been difficult as a dementia specialist — I diagnose my patients with Alzheimer's and then every year I see them get worse and they progress until they die."Both Kisunla and the Japanese drug, Leqembi, are laboratory-made antibodies, administered by IV, that target one contributor to Alzheimer's — sticky amyloid plaque buildup in the brain. Questions remain about which patients should get the drugs and how long they might benefit.
Kisunla and Leqembi are not listed in Health Canada's database of medications approved for use in this country. "Certainly getting an infusion once a month is more appealing than getting it every two weeks," Schindler said.In the company's study, patients were taken off Kisunla once their brain plaque reached low levels. More than 40 per cent of patients stopped taking the drug after one year. Discontinuing the drug could reduce the costs and safety risks of long-term use. It's not yet clear when patients might need to resume infusions.
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