Serotonin 2C receptor in the brain regulates memory in people and animal models, research shows

Baylor College of MedicineJun 28 2024 The findings, published in the journal Science Advances, not only provide new insights into the factors involved in healthy memory but also in conditions associated with memory loss, like Alzheimer's disease, and suggest novel avenues for treatment.

Dr. Yong Xu, co-corresponding author, professor of pediatrics – nutrition and associate director for basic sciences at the USDA/ARS Children's Nutrition Research Center at Baylor "We had previously identified five individuals carrying variants of the serotonin 2C receptor gene that produce defective forms of the receptor," Farooqi said. "People with these rare variants showed significant deficits on memory questionnaires. These findings led us to investigate the association between HTR2C variants and memory deficits in animal models."

Related StoriesThe animal models also enabled the team to dig deeper into how the receptor mediates memory. They discovered a brain circuit that begins in the midbrain where serotonin-producing neurons are located. These neurons project to the vCA1 region, which has abundant serotonin 2C receptors.

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