University of Virginia Health SystemJun 28 2024 Remarkable new research by a University of Virginia undergraduate may help explain recurrent Crohn's disease in children and open the door to new ways to treat or even cure the devastating condition.
The relationship between dysbiosis and inflammation is a long-standing question in Crohn's disease. Rebecca leveraged a pediatric cohort at UVA to show dysbiosis was present even when gut inflammation was controlled. Our study suggests that persistent microbial imbalances might be an important factor in the disease course in children."
Crohn's disease in children Because Crohn's is most common in adults, most research has focused on adult patients. But UVA's new findings shed important light on Crohn's in children. Perhaps counterintuitively, the children with Crohn's also had stronger barriers of epithelial cells lining their intestines. This suggests that existing Crohn's treatments are effective but not fully addressing the underlying issues that drive the disease, the researchers say.
"Our study suggests that returning the bacterial composition to normal might help prevent these patients from relapsing and possibly cure them of Crohn's disease," Jan said."Clinical research is key for improving child health," Marie said. "Rebecca's work brought together experts in infectious disease, pediatric gastroenterology and bioinformatics to address a disease in our pediatric patients at UVA. We are excited to continue this model of collaboration.
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