By Pooja Toshniwal PahariaReviewed by Danielle Ellis, B.Sc.Jun 26 2024 In a recent study published in The Journal of the American College of Cardiology, researchers performed a secondary analysis of the semaglutide treatment effect in people with obesity and heart failure with a preserved left ventricular ejection fraction program that included individuals with diabetes mellitus , stratified by biological sex.
About the study In the present study, researchers analyzed STEP-HFpEF program data to explore the impact of biological sex on anthropometric, cardiovascular health-related, and inflammatory parameters and semaglutide therapy. The researchers excluded individuals with previous or scheduled bariatric surgery, considerable weight change in recent times, or elevated systolic blood pressures, as well as those with severe diabetic maculopathy or retinopathy .
Results Among 1,145 participants , 570 were female. Females had higher LVEF, BMI, CRP, physical limitations, and worse heart failure symptoms and a lower likelihood of having prior histories of coronary heart disease or atrial fibrillation and consuming sodium-glucose cotransporter-2 inhibitors , angiotensin-converting enzyme inhibitors, or angiotensin II receptor blockers compared to men. Baseline 6MWD and KCCQ-CSS values were lower among females.
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