University of California - DavisJun 26 2024 A study published June 21 in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association shows up to a six-month window in which disease progress could be tracked and treatments tested in rhesus macaques.
The sick neurons then cause an inflammatory response mediated early on by microglial cells. Eventually, neurons die, leaving neurofibrillary tangles of tau protein, one of the key markers of Alzheimer’s and other dementing illnesses. Six months of measurable disease progression The researchers injected a vector carrying DNA for two mutated tau proteins into the entorhinal cortex of 12 monkeys. The entorhinal cortex is a key brain region that is involved with memory and is where the disease usually originates in human Alzheimer’s.
The results show that in this model, there is a window of at least two to six months where the progress of the disease can be measured. That opens the possibility of preclinical testing of interventions that target the tau protein.
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