Christina Applegate's Daughter, Sadie, On Having A Parent With MS

On the June 25, 2024 episode of her podcast, MeSsy, Christina Applegate introduced her “favorite guest that we could possibly ever have,” her daughter, Sadie Grace Applegate Le Noble. While Sadie said she presented the idea of being a guest as a joke, her mom and podcast co-host, Jamie-Lynn Sigler, made it a reality so the 13-year-old could speak about what it’s like to have a parent with multiple sclerosis and discuss her own health struggles.

And I do when I can, and I feel incredibly guilty when I can’t, but you’re always pretty darn cool about it, kid.” It also helps that Sadie has been able to relate to her mom to a certain degree. Sadie was diagnosed with postural orthostatic tachycardia syndrome , an incurable condition that brings about a number of symptoms including dizziness, fatigue, tremors and a rapid heart rate, according to the Cleveland Clinic. “I’ve had to live with it for a long time,” Sadie explained.

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