MicroRNAs shed light on aggressive youthful type 2 diabetes

University of OklahomaJun 25 2024 A newly published study from the University of Oklahoma shows that measuring the circulating abundance of microRNAs – which affect insulin-producing beta cells in the pancreas – is likely as effective as measuring the level of sugar in the blood for determining how a young person with the condition will fare.

Type 2 diabetes in youth is so aggressive, and the decline of beta cell function in youth is much more than we see in adults. We believe that predicting what will cause beta cell dysfunction, and eventually preventing that dysfunction, is one of the keys for preventing or treating Type 2 diabetes." Tryggestad's study showed that the microRNAs, at baseline, were nearly as effective as A1C measurement when predicting who would fail to respond to treatment for Type 2 diabetes.

Related Stories"Glucose and A1C are relevant to me as a clinician, but as a clinician-researcher, it's important to have this additional piece of information about microRNAs because it points us toward a mechanism. It's the mechanism that we need to understand to design a prevention. It adds a layer of understanding that we haven't had before," she said.

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