Baylor College of MedicineJun 25 2024 Using a comprehensive approach that included integrating proteomics, genomics and epigenomics data from 10 cancer types, the team identified protein and small protein or peptide targets in cancer tissues and validated many of them experimentally as promising candidates for therapeutic strategies. The study appeared in Cell.
The researchers applied computational tools to integrate proteogenomic data comprising genome-wide information on DNA, RNA and proteins that was generated by the Clinical Proteomic Tumor Analysis Consortium from prospectively collected samples of treatment-naïve primary tumors, many with matched normal adjacent tissues for comparison.
The team applied the data integration approach to systematically identify proteins and genes that are important for cancer growth and development. For instance, proteins that are overexpressed or hyperactive in cancer tissues but not in normal counterparts, and loss of tumor suppressor genes, which can create dependencies on other proteins that could then be therapeutically targeted.
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:
Health Health Latest News, Health Health Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Researchers discover potential new therapy for lethal metabolomic diseaseResearchers at the Abimael Laboratory of Neurometabolism and the Neurometabolomics & Neuroinformatics core at Mount Sinai have discovered a potential new therapy, improved an existing treatment, and identified a disease biomarker in a mouse model of a lethal neurometabolic disease in humans.
Source: medical_xpress - 🏆 101. / 51 Read more »
Researchers investigate the feasibility of new home-administered treatment for binge eating disorderResearchers from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London have investigated the feasibility of a new home-administered treatment for binge eating disorder.
Source: NewsMedical - 🏆 19. / 71 Read more »
Researchers discover new therapeutic target for the treatment of melanoma resistant to targeted therapiesAn international research team led by scientists from the University of Liège has discovered an interesting new therapeutic target for the treatment of melanoma resistant to targeted therapies. Inhibition of the VARS enzyme could prevent this therapeutic resistance by resensitizing tumors resistant to these targeted therapies.
Source: medical_xpress - 🏆 101. / 51 Read more »
Researchers reveal new pathway to improve traumatic brain injury outcomesA team of Australia's leading health researchers has developed a new 'dictionary' to better predict outcomes for people who have experienced a moderate-severe traumatic brain injury (TBI). The work is published in the Journal of Neurotrauma.
Source: medical_xpress - 🏆 101. / 51 Read more »