Alzheimer’s disease, a progressive neurodegenerative disorder affecting approximately 55 million people globally, leads to severe cognitive decline and memory loss. Researchers at the Okinawa Institute of Science and Technology have developed a synthetic peptide, PHDP5, that targets early-stage Alzheimer’s by ensuring the availability of dynamin for vesicle recycling in neurons, demonstrating significant restoration of memory and learning functions in transgenic mice.
Vesicle recycling in the presynaptic terminal at one end of a neuron, showing the role of dynamin during the last step of endocytosis , where the protein cuts off the vesicle from the cell membrane. The vesicle is then filled with neurotransmitters and transported back to the release site of the cell membrane, where the neurotransmitters are released, and the vesicle is recycled. Credit: Kaori Serakaki/OISTA central factor in Alzheimer’s disease is the health of brain synapses.
Using transgenic mice, the researchers have now shown the same restorative effect in vivo. “We were thrilled to see that PHDP5 significantly rescued learning and memory deficits in the mice,” says Dr. Chang. “This success highlights the potential of targeting the dynamin-microtubule interaction as a therapeutic strategy for Alzheimer’s disease.”
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