Jun 21 2024 Colorectal cancer is a leading cause of cancer-related deaths worldwide. The complexity of its pathogenesis, involving genetic mutations, dysregulated signaling pathways, and compromised immune surveillance, presents significant challenges for effective treatment. This review provides a comprehensive overview of the key signaling pathways implicated in CRC, exploring their roles in tumorigenesis and their potential as targets for therapeutic intervention.
Furthermore, the study explores the intricate relationship between colonic epithelial cells and tumorigenesis. It examines the influence of bacterial species like Bacteroides fragilis and Escherichia coli, highlighting their roles in disrupting epithelial integrity and promoting inflammation, thereby contributing to CRC development.
The study also explores the Notch signaling pathway, essential for maintaining intestinal epithelial integrity but often dysregulated in CRC. The review discusses the potential of gamma-secretase inhibitors , initially developed for Alzheimer's disease, as promising agents for targeting the Notch pathway in CRC treatment.
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:
Health Health Latest News, Health Health Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Successful trial for new colorectal cancer treatment highlights promising immunotherapy drugsResults from a new trial indicate that immunotherapy could successfully be used to treat the most common form of colorectal cancer, also known as bowel cancer.
Source: medical_xpress - 🏆 101. / 51 Read more »
Research identifies possible new pathway to treatment of colorectal cancerResearch led by Irving Coy Allen in the Virginia-Maryland College of Veterinary Medicine has unlocked a pathway to possible future treatments for colorectal cancer in humans.
Source: medical_xpress - 🏆 101. / 51 Read more »
Study reveals metformin's role in slowing colorectal cancer cell growthFlinders University researchers have analyzed how an antidiabetic treatment could help control the growth of tumors, potentially paving the way for the design of better cancer treatments.
Source: medical_xpress - 🏆 101. / 51 Read more »
Study shows pre-targeted dual-isotope radionuclide therapy safe and effective in colorectal cancerCombination of alpha- and beta-radionuclide therapy is feasible, tolerable, and effective for colorectal cancer, according to preclinical research presented at the 2024 Society of Nuclear Medicine and Molecular Imaging Annual meeting.
Source: medical_xpress - 🏆 101. / 51 Read more »
Appalachian Kentuckians continue to face higher colorectal cancer mortality ratesResearchers at the University of Kentucky have found that, for much of the past two decades, Appalachian Kentuckians have been more likely to die from colorectal cancer compared to the rest of the state and country's population.
Source: medical_xpress - 🏆 101. / 51 Read more »
The current status of colorectal cancer in ThailandAccording to research led by Prof. Varut Lohsiriwat, Professor of Surgery, Division of General Surgery (Section of Colorectal Surgery) of Siriraj Hospital, at Mahidol University, colorectal cancer (CRC) is the third most common cancer in Thailand, accounting for 11% of the cancer burden.
Source: medical_xpress - 🏆 101. / 51 Read more »