Exploring CD63 as a target in the diagnostics and treatment of cancer

Sponsored Content by ACROBiosystemsReviewed by Aimee MolineuxJun 21 2024 The tetraspanin family member CD63, also referred to as LAMP3, is widely expressed on the membrane surface of macrophages and lymphocytes. CD63 engages in an array of cellular processes, most notably in the formation and release of exosomes.

The increased expression of CD63 in various types of cancer, such as melanoma, breast cancer, and gastric cancer, highlights its potential as a biomarker. For example, elevated levels of CD63 and another protein, Caveolin-1, in plasma exosomes have shown potential in the early detection of melanoma. It also plays an important role in both cell migration and adhesion, as well as tumor cell proliferation and survival. CD63 is, therefore, considered a significant factor in tumor initiation, development and metastasis.

Cell adhesion and migration Epithelial-mesenchymal transition is a process where epithelial cells lose their polarity and adhesion, transforming into mesenchymal cells that have increased motility and invasiveness. CD63 helps to reduce the migration and invasion of melanoma cells by inhibiting markers associated with EMT.

CD63 as a tumor suppressor CD63 has the capacity to hinder the metastatic potential of melanoma cells through the inhibition of EMT markers. Overexpression of CD63 inhibits hepatocellular carcinoma cell migration via the downregulation of interleukin . Insights such as these are key to better understanding the therapeutic potential of targeting CD63 in different cancer treatments.CD63 as tumor promoters. Image Credit: ACROBiosystems

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