New Approach to Treating Melanoma

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An international research team, led by Professor Wenbo Bu of Fudan University and Distinguished Professor Dayong Jin of the University of Technology Sydney, have discovered an innovative method to effectively treat cancer by reactivating suppressed metabolic pathways in cancer cells.

Reviewed by Laura ThomsonJun 20 2024 An international research team, led by Professor Wenbo Bu of Fudan University and Distinguished Professor Dayong Jin of the University of Technology Sydney, discovered an innovative method to effectively treat cancer by reactivating suppressed metabolic pathways in cancer cells, as published in the prestigious journal Nature Nanotechnology.

Tyrosine’s bioavailability is restricted in living beings. However, the researchers employed a novel nanotechnology approach to packaging it into small particles known as nanomicelles. These particles are attracted to cancer cell membranes and rapidly break down, increasing absorption. Uncontrolled rapid growth is a key feature that distinguishes cancer cells from normal cells. In cancer cells some metabolic pathways are over-activated, and others are suppressed, to create the environment necessary for rapid spread.

Related StoriesDifferent nutrients will have varying effects on cancer. Melanoma cells arise from melanocytes, which are skin cells that create melanin. Tyrosine is required to create melanin and can enhance melanin production, which explains its effectiveness with melanoma.

 

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