In patients with irritable bowel syndrome , a dietitian-guided 12-week strict low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols diet improves quality of life without altering nutritionally related blood parameters or macro- and micronutrient intake.
Between May 2019 and July 2021, researchers prospectively enrolled participants with moderate to severe IBS and diarrhea or mixed stool patterns who followed a 12-week strict LFD intervention guided by a registered dietitian. Blood samples were collected, body weight was measured, and IBS severity and QoL were assessed at baseline and after 4 weeks and 12 weeks.Thirty-six participants completed the intervention.
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