Antioxidants combat high-fat diet-induced female reproductive issues, study reveals

By Dr. Sanchari Sinha Dutta, Ph.D.Jun 11 2024 In a systematic review published in the journal Frontiers in Nutrition, researchers in Italy have provided a comprehensive overview of the impact of biological matrices with antioxidant properties in mitigating high-fat diet-induced female reproductive complications.

Biological matrices that can positively impact the female reproductive system include carbocyclic sugar, phytonutrients, organosulfur compounds, hormones, neuropeptides, organic acids, and vitamins. These matrices mostly contain a variety of antioxidants that help mitigate ROS-induced oxidative damage in the body.

In rodent models of high-fat diet-induced oxidative stress, a diet containing a combination of two phytonutrients, barley, and dates, has been found to preserve ovarian follicles, increase follicle development and proliferation, restore ovarian stroma, and increase endogenous enzymatic antioxidant levels.

In obese rats, a multi-antioxidant supplement, including organosulfur compound, phytonutrients, vitamin E, and Coenzyme Q10, has been found to reduce ovarian inflammation and follicular atresia and mitigate obesity-induced infertility. Organosulfur compounds have been found to ameliorate infertility caused by high-fat diet-induced obesity. Dietary interventions containing ferulic acid, kaempferol, malvidin, caffeoylquinic acid, and quercetin derivatives, as well as the combined use of myo-inositol and α-lipoic acid, have been found to protect against ovarian cycle disruption and reduce ovarian degenerative changes caused by high-fat diet-induced oxidative stress.

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