CHICAGO — Tumor debulking does not improve survival in multiorgan metastatic colorectal cancer , according to a phase 3 trial presented at the
The use of tumor debulking to treat metastases for multiorgan metastatic CRC has been based on retrospective series that suggest a benefit as well as the emergence of less invasive options, such as thermal ablation and stereotactic radiation, Gootjes explained.Major Kenneth Lee Baseline characteristics were well balanced between the groups. About 30% of patients had right-sided primaries, more than half had amutation, and the number of patients with baseline lactate dehydrogenase above 250 U/L and baseline carcinoembryonic antigen above 200 ng/mL was essentially equal between the groups.
In subgroup analyses, the authors found no survival differences in patients with liver and lung metastases only, peritoneal metastases, or durable responses to systemic therapy.
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