This survival data along with radiographic improvements are indicative of positive treatment effects, which highlights the potential of IN8bio's genetically modified, chemotherapy-resistant gamma-delta T cells as a potential first-in-class therapy for patients with newly diagnosed glioblastoma.
The clinical trial was led by Burt Nabors, M.D., in collaboration with IN8bio. Nabors is a professor of neurology at UAB, division director of Neuro-Oncology and a senior scientist in the O'Neal Comprehensive Cancer Center at UAB. Gamma-delta T cells are a specialized population of T cells that possess unique properties, including the ability to differentiate between healthy and diseased tissue.
The Phase 1 study assessed the safety and preliminary efficacy of adding DeltEx DRI gamma-delta T cells to maintenance therapy with temozolomide. The trial assessed the administration of 10 million cells per dose across three different dosing regimens increasing from a single dose delivered on Cycle 1, Day 1 during maintenance in Cohort 1, to three doses delivered on Day 1 of Cycles 1-3 in Cohort 2, to six doses delivered on Day 1 of Cycles 1-6 in Cohort 3.
These preliminary clinical data were presented at a poster session of the 2024 American Society of Clinical Oncology, or ASCO, Annual Meeting in Chicago. Mina Lobbous, M.D., assistant professor of neurology at Cleveland Clinic was the poster presenter.Scientists are developing and validating a patent-pending novel immunotherapy to be used against glioblastoma brain tumors. Glioblastomas are almost always lethal with a median survival time of 14 ...