Heart healthy behaviors may help reverse rapid cell aging

The benefit of better heart health may be associated with the positive impact of heart healthy lifestyle factors on biological aging , according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

Researchers examined health data for 5,682 adults who were enrolled in the Framingham Heart Study, an ongoing, large, multigenerational research project aimed at identifying risk factors for heart disease. Using interviews, physical exams and laboratory tests, all participants were assessed using the American Heart Association's Life's Essential 8 tool. The tool scores cardiovascular health between 0-100 using a composite of four behavioral measures and four clinical measurements .

"While there are a few DNA methylation-based, biological age calculators commercially available, we don't have a good recommendation regarding whether people need to know their epigenetic age," Ma said."Our message is that everyone should be mindful of the eight heart disease and stroke health factors: eat healthy foods; be more active; quit tobacco; get healthy sleep; manage weight; and maintain healthy cholesterol, blood sugar and blood pressure levels.

Participants were followed for an average of 14 years for children of original participants and 11 years for the grandchildren. The four tools to measure DNA methylation-based epigenetic age scores were based on established algorithms for DunedinPACE Score, PhenoAge, DNAmTL and GrimAge. A fifth tool, GrimAge PGS, assessed genetic tendency towards accelerated biological aging.

According to the American Heart Association's 2024 Heart Disease and Stroke Statistics, heart disease and stroke claimed more lives in the U.S. in 2021 than all forms of cancer and chronic lower respiratory disease combined, and also accounted for approximately 19.91 million global deaths.Madeleine Carbonneau, Yi Li, Brenton Prescott, Chunyu Liu, Tianxiao Huan, Roby Joehanes, Joanne M. Murabito, Nancy L. Heard‐Costa, Vanessa Xanthakis, Daniel Levy, Jiantao Ma.

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