By Pooja Toshniwal PahariaMay 28 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal Nature Medicine, researchers conducted a randomized, double-blinded, placebo-controlled phase 2a trial to investigate the safety and efficacy of LM11A-31 in managing Alzheimer's disease through p75 neurotrophin receptor modulation.
About the study In the present randomized clinical trial, researchers investigated whether LM11A-31 could delay the progression of Alzheimer's disease by modulating p75NTR in humans. The primary outcome was safety and tolerability, assessed using the Columbia Suicide Severity Rating Scale , vital signs, blood pressure, and hematological parameters. The study used structural magnetic resonance imaging , fluorodeoxyglucose-positron emission tomography , and CSF biomarkers to assess secondary cognitive outcomes in Alzheimer's disease. AD indicators include tau phosphorylated at Thr181, total tau protein, Aβ40, Aβ42, and AChE activity.
Results The study found that LM11A-31 is safe and acceptable, with no serious safety concerns. Pervasive side effects include headache, diarrhea, eosinophilia, and nasopharyngitis, with gastrointestinal problems and eosinophilia being the most prevalent reasons for stopping. The 400-mg group saw greater medication discontinuations than the 200-mg and placebo groups. MRI found no concerns regarding medication safety, including amyloid-related imaging abnormalities.
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