Discovery of promising protein candidate opens new avenues for treating metabolic disorders

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Metabolic Disease News

Protein,Endocrinology,Genes

A University of Saskatchewan (USask) research team's discovery of the additional health benefits of an appetite-suppressing protein has doubled the potential for scientists to find new avenues for treating obesity and metabolic disorders in animals and people.

May 28 2024University of Saskatchewan A University of Saskatchewan research team's discovery of the additional health benefits of an appetite-suppressing protein has doubled the potential for scientists to find new avenues for treating obesity and metabolic disorders in animals and people.

While the lipid-lowering effect of nesfatin-1 was previously reported, Unniappan said identifying NLP and understanding its lipid-lowering capabilities in human cells represent new advancements in the field of endocrinology. Unniappan and his research team have been at the forefront of nesfatin-1 research. Discovered in 2006 by a group of researchers in Japan, nesfatin-1 was initially recognized for its ability to suppress food intake.

Discovering such results-;that administering NLP reduces lipid levels, while disrupting its production alters lipid metabolism-;reinforces its pivotal role in metabolic regulation.

 

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Researchers identify promising protein candidate for metabolic disease treatmentUniversity of Saskatchewan (USask) research, which has been published in Communications Biology, highlights the discovery of the lipid-lowering effects of nesfatin-1-like peptide (NLP). This newly identified peptide—or small protein—is a close relative of nesfatin-1 (NESF-1), which regulates feed intake and body weight.
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