Study reveals pivotal role of the circadian clock in enhancing checkpoint inhibitor cancer therapy

May 28 2024University of California - Irvine Checkpoint inhibitors block different proteins from binding to tumor cells, allowing the immune system's T cells to kill the tumor.

Disruption of the internal biological pacemaker is an inherent aspect of modern society that may contribute to the rising incidence of many cancer types. We found that proper regulation of circadian rhythms is necessary to suppress inflammation and support peak immune function. Understanding precisely how circadian disruption promotes disease progression could lead to behavior modification to reduce cancer risk.

Related StoriesWhile this study represents a significant step forward in defining circadian control of anti-tumor immunity, the team believes future research should focus on exploring additional factors and cell types influencing time-of-day response to checkpoint inhibitor therapy.

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